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ALP (Alkaline Phosphatase) is an enzyme produced in the liver, bile ducts, and bones. In adults, elevated ALP most commonly indicates bile duct obstruction, liver disease, or bone disorders with increased turnover. Because ALP is produced by both liver and bone, GGT is used alongside it to identify the source: high ALP with high GGT points to the liver; high ALP with normal GGT points to bone.
Also known as: Alk, Alk Phos, Alk. Phos., Alkaline phos, Alkaline Phosph, Alkaline Phosphatase, Alkaline phosphatase (ALP), ALKP
High ALP originates from liver or bone. Liver causes include bile duct obstruction. Bone causes include Paget's disease, fracture healing, and vitamin D deficiency. Low ALP occurs with zinc deficiency.
Standard range is 44-147 U/L. Functional practitioners target 50-90 U/L. Growing children normally run 2-3 times adult levels.