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GGT (Gamma-Glutamyl Transferase) is a liver enzyme uniquely sensitive to alcohol intake, non-alcoholic fatty liver disease, and bile duct stress — often rising before ALT, AST, or ALP show any measurable change. Persistently elevated GGT, even at levels still within many labs' 'normal' range, is an independent predictor of cardiovascular disease, metabolic syndrome, and liver disease progression. Alcohol reduction typically normalizes GGT within 2–4 weeks, making it a useful monitoring tool.
Also known as: Gama glutamil transferasa, Gamma glutamyl transferase, Gamma glutamyl transpeptidase, Gamma GT, Gamma-Glutamyl Transferase, Gamma-Glutamyltransferase, Gamma-glutamyltransférase, Gamma-GT
High GGT is the most sensitive marker for bile duct problems and alcohol consumption. It also rises with metabolic syndrome and insulin resistance. Low GGT associates with hypothyroidism.
Standard labs accept up to 55-65 U/L. Functional practitioners target below 20 U/L for men and below 15 U/L for women. GGT above 25 U/L correlates with cardiovascular mortality.