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Transferrin saturation (iron % saturation) is the percentage of transferrin binding sites currently occupied by iron — calculated by dividing serum iron by TIBC and multiplying by 100. A saturation below 20% with low ferritin confirms iron deficiency; a saturation above 45–50% raises concern for hereditary haemochromatosis, a common genetic condition causing iron overload that can damage the liver, heart, and joints if untreated. This marker is the recommended first-line screen for haemochromatosis.
Also known as: % Iron Saturation, % Saturation, Iron % Saturation, Iron Satn, Iron Saturation, SAT, Satn, Transferrin Sat
High iron saturation above 45% suggests hemochromatosis or iron overload. Low iron saturation below 20% indicates iron deficiency or chronic disease.
Standard range is 20-50%. Functional optimal is 25-35%. Saturation above 45% triggers hemochromatosis screening.