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Total iron binding capacity (TIBC) measures the maximum amount of iron that the blood's carrier protein (transferrin) can hold, serving as an indirect measure of transferrin levels. TIBC rises when iron stores are low — the body increases transferrin production to capture every available iron molecule — and falls in iron overload or chronic inflammation. TIBC is most useful when interpreted together with serum iron and ferritin: low iron with high TIBC and low ferritin confirms classic iron-deficiency anemia.
Also known as: dTIBC, IBC, Iron Binding Capacity, Iron-Binding Capacity, TIBC, Total iron binding, Total Iron Binding Capacity
High TIBC means your body is producing more transferrin to capture iron, a hallmark of iron deficiency. Low TIBC occurs in iron overload, chronic inflammation, or liver disease.
Standard range is 250-370 ug/dL. Functional range targets 275-325 ug/dL. TIBC above 350 ug/dL often indicates early iron depletion.