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Lipoprotein (a) — or Lp(a) — is a genetically determined lipid particle that dramatically amplifies cardiovascular risk independent of LDL cholesterol. Unlike LDL, Lp(a) is largely unresponsive to diet, exercise, or statins — its level is set almost entirely by the genes you inherited. Testing Lp(a) once in a lifetime is recommended by major cardiology guidelines; a high result indicates elevated lifetime risk that demands more aggressive management of all modifiable risk factors.
Also known as: Lipoprotein (a), Lipoprotein (little a), Lipoprotein a, Lipoprotein(a), Lp(a), LPa
High Lp(a) is primarily genetically determined and is one of the strongest independent risk factors for cardiovascular disease and aortic valve stenosis. Low Lp(a) is cardiovascularly protective.
Risk threshold is above 75 nmol/L. Optimal is below 30 nmol/L. Lp(a) is over 90% genetically determined. Every adult should measure Lp(a) at least once.