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ApoB (Apolipoprotein B) is a protein that coats every atherogenic lipid particle — LDL, VLDL, IDL, and lipoprotein(a) — making it a direct count of cardiovascular risk particles rather than just the cholesterol they carry. Evidence consistently shows that ApoB is a better predictor of heart attack and stroke risk than LDL cholesterol alone, particularly in people with insulin resistance or high triglycerides. Major cardiology guidelines increasingly recommend ApoB as the primary lipid biomarker.
Also known as: APO, Apo B, ApoB, ApoB-100, Apolipo, Apolipoprot, Apolipoprotein B, Apolipoprotein B-100
High ApoB means more atherogenic particles are circulating, directly increasing arterial plaque formation. Low ApoB reflects fewer atherogenic particles and lower cardiovascular risk.
Standard targets are below 90 mg/dL. Leading lipidologists target below 60 mg/dL. ApoB is increasingly recognized as the single best lipid marker for cardiovascular risk.