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MCHC (Mean Corpuscular Haemoglobin Concentration) measures the concentration of haemoglobin within the average red blood cell — how densely packed the haemoglobin is. Low MCHC reflects hypochromic (pale, iron-deficient) red cells; high MCHC is less common but is characteristically seen in hereditary spherocytosis, a genetic red cell membrane disorder. MCHC is also a quality-control marker for laboratory analysers, since it has a very narrow physiological range and can flag haemolysed samples or lab errors.
Also known as: MCHC, Mean Cell Hemoglobin Concentration, Mean Corpuscular Hemoglobin Concentration
High MCHC is characteristically seen in hereditary spherocytosis. Low MCHC confirms hypochromic red cells from iron deficiency or thalassemia.
Standard range is 32-36 g/dL. MCHC has the narrowest physiological range of any CBC parameter. Functional targets are 33-35 g/dL.