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DHEA-S (Dehydroepiandrosterone Sulfate) is the most abundant steroid hormone in circulation and serves as the precursor for the body's production of testosterone and estrogen. Levels peak in the mid-20s and decline steadily with age — this decline is one of the most consistent hormonal signatures of biological aging. Low DHEA-S is associated with fatigue, low libido, reduced muscle mass, depression, and impaired immune function; abnormally high levels in women raise concern for adrenal androgen excess.
Also known as: Dehydroepiandrosterone Sulfate, DHEA, DHEA Sulfate, DHEA-S, DHEA-SO4, DHEA-Sulfate, DHEAS, Prasterone
High DHEA-S can indicate adrenal hyperplasia, PCOS, or supplementation. Low DHEA-S correlates with aging, adrenal insufficiency, and chronic stress.
Ranges are highly age-dependent. Functional practitioners target values equivalent to a healthy 25-30-year-old: 250-400 ug/dL for men and 150-300 ug/dL for women.