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Large HDL particles are the most functionally active subclass of HDL — they are the primary drivers of reverse cholesterol transport, removing cholesterol from artery walls and returning it to the liver for excretion. Low large HDL is more predictive of cardiovascular risk than total HDL cholesterol, because it captures the functional, not just the quantitative, aspect of HDL. Aerobic exercise, niacin, and alcohol reduction (in excess drinkers) are the most effective ways to increase large HDL particle concentration.
Also known as: Alfa, HDL particle concentration, HDL particle number, High density lipoproteins
High large HDL particles are the most cardioprotective subfraction, performing reverse cholesterol transport most efficiently. Low large HDL indicates impaired cholesterol clearance from arteries.
Optimal large HDL is above 5.0 umol/L for women and above 4.0 umol/L for men. High-intensity exercise preferentially increases large HDL.