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MPV (Mean Platelet Volume) measures the average size of platelets — larger platelets are younger, more metabolically active, and more reactive, with a greater capacity to form clots. Elevated MPV is associated with increased platelet reactivity and higher cardiovascular risk, independent of platelet count, and is seen in conditions like acute myocardial infarction, metabolic syndrome, and diabetes. Low MPV alongside low platelet count points toward bone marrow suppression rather than peripheral destruction, aiding the differential diagnosis of thrombocytopenia.
Also known as: Mean Platelet Volume, MPV, Piastrina, Plaqueta, Thrombozyt, Volume moyen plaquettaire, Volume plaquetário Médio (MPV), 혈소판 평균 용적
High MPV indicates larger, younger, more reactive platelets seen in immune thrombocytopenia, diabetes, and cardiovascular disease. Low MPV suggests bone marrow suppression.
Standard range is 7.5-12.0 fL. Optimal is 8.5-10.5 fL. Elevated MPV is an independent predictor of heart attack, stroke, and DVT risk.