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Total protein measures the combined concentration of albumin and globulins in the blood, providing a broad overview of nutritional status, liver function, and immune activity. Low total protein indicates malnutrition, liver disease (reduced synthesis), kidney disease (protein loss), or malabsorption. An elevated total protein — driven by high globulins — can signal chronic inflammation, chronic infection, or a plasma cell disorder like multiple myeloma. The albumin-to-globulin ratio provides additional diagnostic clarity.
Also known as: Protein Total, Protein, Total, Total protein, TP
High total protein results from dehydration, chronic inflammation, or plasma cell disorders like multiple myeloma. Low total protein indicates malnutrition, liver disease, or kidney disease.
Standard range is 6.0-8.3 g/dL. Functional practitioners target 6.8-7.5 g/dL. The albumin-to-globulin ratio provides more diagnostic value than total protein alone.